While connecting the dots to all the possibly known diseases, it lead us to a single root cause, an increased level of free-radicals. Apart from the external sources, internally sources as well, trigger the natural-aging-clock i.e. the length of the telomere. The present study was focused on the chemical constituents being, polyphenolic tannins (ellagic acid, punicallin, punicalagin) being converted into urolithins. Ageing was induced by oral administration of soft-drink for 6 weeks in positive control group resulted increase in body weight, lipid-peroxidase & low-density lipids. The oral administration dose of pomegranate aqueous peel extract in group T1(a) 50mg/kg & group T1(b) 10 mg/kg of body weight & pomegranate fruit juice in group T2(a) 2ml/kg & T2(b) 3 ml/kg of body weight, was given for 3 weeks. Furthermore, the combination of both aqueous peel extract & fruit juice in group T3 was 100mg/kg & 3ml/kg of body weight administered orally. The pomegranate aqueous peel extract shown to be a potent antioxidant than the pomegranate fruit juice. Whereas, among all the treatment groups, group T3 shown significant increase in superoxidases, reduced glutathione, free radical scavenging activity, high-density lipids & memory retention as compared to the positive control group.
free radicals, telomere, antioxidant, ORAC, Punica granatum L., ellagic acid, punicallin, punicallagin, polyphenol, polyphenolic tannins, urolithins, anti-aging
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